1 In 8 Cancer Cases Worldwide Are Due to Infections

An estimated 2.3 million cancer cases worldwide in 2024, about one in eight, were attributable to infections, according to a study published in The Lancet Oncology. “This recent Lancet data is a profound reminder that a significant portion of our global cancer burden is fundamentally preventable,” said David Greenberg, MD, of Hackensack Meridian Jersey Shore University Medical Center, in a news release. “We have historically siloed infectious diseases and oncology, but they are deeply intertwined. By shifting our focus toward aggressive infection control, we can literally vaccinate and treat our way out of millions of future cancer diagnoses.”

The study found that an estimated 2.3 million new cancer cases were attributable to infections globally in 2024, equivalent to 12% of all cancer cases. Of these, the largest number (760,000 cases, or 4%) were caused by H. pylori, followed by HPV (750,000 cases, or 4%), HBV (360,000 cases, or 2%), EBV (260,000 cases, or 1%) and HCV (160,000 cases). More than three quarters of infection-attributable cancers occurred in low- and middle-income countries. Eastern Asian had the largest burden, with 990,000 cases (42% of the global total). Rates were also higher than the global average in sub-Saharan Africa, Central and Eastern Europe and Southeast Asia.